【摘要】Hydrogen sulfide(H2S) is an important messenger for its strong anti-inflammatory effects, which may be involved in multiple cardiovascular diseases. In our previous study, we revealed that H2S attenuated diabetesaccelerated atherosclerosis through suppressing oxidative stress. Here we report that GYY4137, a H2S donor,reduced the plaque formation of aortic roots and the levels of both intercellular cell adhesion molecule 1(ICAM1)and vascular cell adhesion molecule 1(VCAM1) in diabetes-accelerated atherosclerotic cells and mouse models.The inflammatory factors of TNF-α, IL-1β, IL-6, and MCP1 were also significantly reduced by GYY4137.Mechanically, GYY4137 suppressed the activation of pyrin domain containing protein 3(NLRP3) inflammasome in diabetes-accelerated atherosclerosis conditions. Upon knockdown of NLRP3, the increase of ICAM1 and VCAM1 caused by high glucose and ox LDL could be reversed, indicating that H2S protected the endothelium by inhibiting the activity of NLRP3 inflammasome. In conclusion, our study indicates that GYY4137 effectively protects against the development of diabetes-accelerated atherosclerosis by inhibiting inflammasome activation.
【关键词】
《建筑知识》 2015-05-12
《中国医疗管理科学》 2015-05-12
《中国医疗管理科学》 2015-05-12
《中国医疗管理科学》 2015-05-12
《广州大学学报(社会科学版)》 2015-07-03
《重庆与世界》 2015-07-01
《阅江学刊》 2015-07-02
《中外医疗》 2015-07-03
Copyright © 2013-2016 ZJHJ Corporation,All Rights Reserved
发表评论
登录后发表评论 (已发布 0条)点亮你的头像 秀出你的观点